What is VIP?
VIP (vasoactive intestinal peptide) is a 28-amino-acid neuropeptide found throughout the nervous system, gut and lungs.
How does VIP work?
It binds VPAC receptors to relax smooth muscle, widen blood vessels and regulate immune responses.
What are researchers studying?
- ●Lung inflammation and respiratory failure (as aviptadil)
- ●Gut motility and secretion
- ●Circadian rhythm regulation
Where does the evidence stand?
A synthetic form, aviptadil, has been tested in clinical trials. Not approved by the FDA for general use.
Quick facts
- Research area
- Immune
- Also known as
- Vasoactive Intestinal Peptide
- Third-party lab results
- 1 published COAs →
- Tested vendors tracking it
- 2 vendors →
Recent peer-reviewed research
The most relevant VIP studies from the last three years, via PubMed (U.S. National Library of Medicine).
- VIPoma· 2025 Jan · PubMed ↗
- Tau, ADNP, and sexCytoskeleton (Hoboken, N.J.) · 2024 Jan · PubMed ↗
- Hypothalamic clock governs circadian painScience (New York, N.Y.) · 2026 Mar 19 · PubMed ↗
- Proinflammatory cytokines and neuropeptides in psoriasis, depression, and anxietyActa physiologica (Oxford, England) · 2025 Mar · PubMed ↗
- Risk factors for catheter-associated bloodstream infection in hemodialysis patients: A meta-analysisPloS one · 2024 · PubMed ↗
Related research guides
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This guide summarizes published research for educational purposes only. It is not medical advice and does not describe how to use VIP. Citations link to PubMed and are listed for reference — we haven't reviewed or endorsed their findings. Products referenced on The Peptide Audit are sold by third parties for laboratory research use only and are not for human consumption.