What is VIP?

Human clinical studiesImmune research · Last reviewed September 28, 2026

VIP (vasoactive intestinal peptide) is a 28-amino-acid neuropeptide found throughout the nervous system, gut and lungs.

How does VIP work?

It binds VPAC receptors to relax smooth muscle, widen blood vessels and regulate immune responses.

What are researchers studying?

●Lung inflammation and respiratory failure (as aviptadil)
●Gut motility and secretion
●Circadian rhythm regulation

Where does the evidence stand?

Human clinical studies

A synthetic form, aviptadil, has been tested in clinical trials. Not approved by the FDA for general use.

Quick facts

Research area: Immune
Also known as: Vasoactive Intestinal Peptide
Third-party lab results: 1 published COAs →
Tested vendors tracking it: 2 vendors →

Recent peer-reviewed research

The most relevant VIP studies from the last three years, via PubMed (U.S. National Library of Medicine).

TAGLN2 promotes mesenchymal circulating tumor cell-associated metastasis through the CSNK1E-YAP Axis with concomitant EMT induction and metabolic remodeling in hepatocellular carcinoma
Cellular signalling · 2026 Dec · PubMed ↗
Untargeted Lipidomic Profiling of Amniotic Fluid Reveals Dysregulated Lipid Metabolism in Healthy Normal-Weight Mothers with Fetal Macrosomia
Nutrients · 2024 Nov 6 · PubMed ↗
Serotonergic and glutamatergic mechanisms converge in ketamine's rapid responses
Trends in neurosciences · 2026 May · PubMed ↗
Layer 1 NDNF interneurons are specialized top-down master regulators of cortical circuits
Cell reports · 2024 May 28 · PubMed ↗
Vasoactive intestinal peptide modified defect-engineered ZnO(x)-Au-NaBH(4) nanoplatform inducing pyroptosis in fibroblast-like synoviocytes for therapy of rheumatoid arthritis
International journal of biological macromolecules · 2026 Jan · PubMed ↗

Related research guides

What is KPV?What is Thymosin Alpha-1?What is LL-37?What is ARA-290?

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This guide summarizes published research for educational purposes only. It is not medical advice and does not describe how to use VIP. Citations link to PubMed and are listed for reference — we haven't reviewed or endorsed their findings. Products referenced on The Peptide Audit are sold by third parties for laboratory research use only and are not for human consumption.