What is KPV?

KPV is a tripeptide (lysine-proline-valine) that makes up the tail end of alpha-melanocyte-stimulating hormone (α-MSH).

How does KPV work?

It appears to calm inflammatory signaling inside cells (the NF-κB pathway) without the pigment-darkening effects of the full hormone.

What are researchers studying?

• ●Inflammatory bowel disease models
• ●Skin inflammation
• ●Targeted delivery with nanoparticles

Where does the evidence stand?

Quick facts

Research area

Immune

Sequence

Lys-Pro-Val

Third-party lab results

6 published COAs →

Tested vendors tracking it

2 vendors →

Recent peer-reviewed research

The most relevant KPV studies from the last three years, via PubMed (U.S. National Library of Medicine).

1. Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers
   Science advances · 2026 Jan 16 · PubMed ↗
2. KPV and RAPA Self-Assembled into Carrier-Free Nanodrugs for Vascular Calcification Therapy
   Advanced healthcare materials · 2024 Dec · PubMed ↗
3. A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review
   The Journal of sports medicine and physical fitness · 2026 Jul · PubMed ↗
4. KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling
   Tissue & cell · 2026 Aug 9 · PubMed ↗
5. Lysine-proline-valine peptide attenuates hepatic lipid accumulation through ROS-dependent regulation of the PPARγ pathway in HepG2 cells
   Cytotechnology · 2026 Jun · PubMed ↗

Compare KPV

Related research guides

This guide summarizes published research for educational purposes only. It is not medical advice and does not describe how to use KPV. Citations link to PubMed and are listed for reference — we haven't reviewed or endorsed their findings. Products referenced on The Peptide Audit are sold by third parties for laboratory research use only and are not for human consumption.