What is Thymosin Alpha-1?
Thymosin alpha-1 is a 28-amino-acid peptide originally isolated from the thymus, the organ where immune T-cells mature.
How does Thymosin Alpha-1 work?
It acts on immune cells through toll-like receptors and has been shown to influence T-cell maturation and the body’s response to infection.
What are researchers studying?
- ●Chronic hepatitis B and C
- ●Immune response to vaccines
- ●Severe infections and sepsis
Where does the evidence stand?
Approved as a drug (thymalfasin, Zadaxin) in several countries outside the U.S. Not approved by the FDA.
Quick facts
- Research area
- Immune
- Also known as
- TA1, Ta-1, Thymosin Alpha 1
- Third-party lab results
- 3 published COAs →
- Tested vendors tracking it
- 2 vendors →
Recent peer-reviewed research
The most relevant Thymosin Alpha-1 studies from the last three years, via PubMed (U.S. National Library of Medicine).
- The efficacy and safety of thymosin alpha-1 combined with lenvatinib plus sintilimab in unresectable hepatocellular carcinoma: a retrospective studyScientific reports · 2025 Apr 22 · PubMed ↗
- Exploiting the potential of in situ forming liquid crystals: development and in vitro performance of long-acting depots for peptide drug thymosin alpha 1 subcutaneous administrationDrug delivery · 2025 Dec · PubMed ↗
- Phenotypic drug discovery: a case for thymosin alpha-1Frontiers in medicine · 2024 · PubMed ↗
- Immune-Enhancing Treatment among Acute Necrotizing Pancreatitis Patients with Metabolic Abnormalities: A Post Hoc Analysis of a Randomized Clinical TrialGut and liver · 2024 Sep 15 · PubMed ↗
- Thymosin Alpha-1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal NecroptosisAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 Sep 3 · PubMed ↗
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This guide summarizes published research for educational purposes only. It is not medical advice and does not describe how to use Thymosin Alpha-1. Citations link to PubMed and are listed for reference — we haven't reviewed or endorsed their findings. Products referenced on The Peptide Audit are sold by third parties for laboratory research use only and are not for human consumption.