Sermorelin vs Tesamorelin
Key differences, research and prices — side by side.
Both are GHRH analogues. Sermorelin is the natural first 29 amino acids of GHRH and was once FDA-approved (Geref) for children with growth-hormone deficiency. Tesamorelin is a stabilized version that is FDA-approved (Egrifta) for abdominal fat in HIV-associated lipodystrophy.
| Sermorelin | Tesamorelin | |
|---|---|---|
| What it is | Sermorelin is a synthetic copy of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH 1-29). | Tesamorelin is a stabilized analogue of growth-hormone-releasing hormone (GHRH). |
| How it works | It activates the pituitary’s GHRH receptor to release growth hormone in natural pulses. | It stimulates the pituitary to release growth hormone, which raises IGF-1 levels. |
| Research areas |
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| Evidence | Approved drug | Approved drug |
| Regulatory status | Was FDA-approved (Geref) for children with growth-hormone deficiency; the branded product was discontinued in 2008 for commercial reasons. | FDA-approved (Egrifta) since 2010 for reducing excess abdominal fat in adults with HIV-associated lipodystrophy. |
| Research area | GH Secretagogues | GH Secretagogues |
| Sequence | — | — |
| Lowest price | $5.95/mg → | $6.12/mg → |
| Tested vendors | 2 | 2 |
| Third-party lab results | 3 COAs | 6 COAs |
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Educational comparison of published research — not medical advice, and not a recommendation of either compound. Prices are for reference only. Compounds referenced are sold by third parties for laboratory research use only and are not for human consumption.