Tesamorelin vs Ipamorelin
Key differences, research and prices — side by side.
The key difference
Tesamorelin is an FDA-approved GHRH analogue (Egrifta) acting on the GHRH receptor. Ipamorelin is an investigational ghrelin-receptor agonist that reached clinical trials but was not approved.
| Tesamorelin | Ipamorelin | |
|---|---|---|
| What it is | Tesamorelin is a stabilized analogue of growth-hormone-releasing hormone (GHRH). | Ipamorelin is a synthetic five-amino-acid peptide from the “growth-hormone secretagogue” family. |
| How it works | It stimulates the pituitary to release growth hormone, which raises IGF-1 levels. | It mimics ghrelin at the GHS-R1a receptor to trigger growth-hormone release, and is notable for affecting cortisol and prolactin less than older compounds. |
| Research areas |
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| Evidence | Approved drug | Human clinical studies |
| Regulatory status | FDA-approved (Egrifta) since 2010 for reducing excess abdominal fat in adults with HIV-associated lipodystrophy. | Reached human trials but was not approved. Not approved by the FDA. Prohibited in sport by WADA. |
| Research area | GH Secretagogues | GH Secretagogues |
| Sequence | — | Aib-His-D-2Nal-D-Phe-Lys-NH2 |
| Lowest price | $6.12/mg → | $3.96/mg → |
| Tested vendors | 2 | 2 |
| Third-party lab results | 6 COAs | 3 COAs |
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Educational comparison of published research — not medical advice, and not a recommendation of either compound. Prices are for reference only. Compounds referenced are sold by third parties for laboratory research use only and are not for human consumption.