SS-31: peptide of the week

What is SS-31?

SS-31 (elamipretide) is a small synthetic tetrapeptide designed to concentrate inside mitochondria, the energy-producing structures of cells.

How it works

It binds cardiolipin, a lipid in the inner mitochondrial membrane, which is thought to help stabilize the machinery that produces cellular energy.

What researchers are studying

• ●Mitochondrial disease, including Barth syndrome
• ●Heart failure and kidney injury models
• ●Age-related decline in muscle function

Where the evidence stands: Elamipretide has been studied in human clinical trials and received FDA accelerated approval in 2025 for Barth syndrome, a rare mitochondrial disease.

Recent peer-reviewed research

1. SS-31@Fer-1 Alleviates ferroptosis in hypoxia/reoxygenation cardiomyocytes via mitochondrial targeting
   Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025 Feb · PubMed ↗
2. Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential
   International journal of molecular sciences · 2025 Jan 23 · PubMed ↗
3. Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
   Sports medicine (Auckland, N.Z.) · 2026 Aug · PubMed ↗

New lab results that week

• GLP-2 10mg · Mile High Compounds · Third-party labView report ↗
• GLP-3 10mg · Mile High Compounds · Third-party labView report ↗
• GLP-3 5mg · Mile High Compounds · Third-party labView report ↗
• GLP-3 50mg · Mile High Compounds · Third-party labView report ↗