What is PT-141?
PT-141 (bremelanotide) is a synthetic peptide derived from melanotan-2.
How does PT-141 work?
It activates melanocortin receptors in the brain (mainly MC4R) that are involved in sexual arousal pathways, rather than acting on blood flow.
What are researchers studying?
- ●Hypoactive sexual desire disorder (HSDD)
- ●Melanocortin signaling in the brain
Where does the evidence stand?
FDA-approved in 2019 (Vyleesi) for premenopausal women with hypoactive sexual desire disorder.
Quick facts
- Research area
- Reproductive
- Also known as
- Bremelanotide, PT141
- Third-party lab results
- 4 published COAs →
- Tested vendors tracking it
- 2 vendors →
Recent peer-reviewed research
The most relevant PT-141 studies from the last three years, via PubMed (U.S. National Library of Medicine).
- Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future PerspectivesInternational journal of molecular sciences · 2026 Apr 27 · PubMed ↗
- Bremelanotide· 2006 · PubMed ↗
- Intravenous peptides and amino acids for erectile dysfunction: a narrative review of current applications and future directionsExpert opinion on pharmacotherapy · 2025 Apr · PubMed ↗
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This guide summarizes published research for educational purposes only. It is not medical advice and does not describe how to use PT-141. Citations link to PubMed and are listed for reference — we haven't reviewed or endorsed their findings. Products referenced on The Peptide Audit are sold by third parties for laboratory research use only and are not for human consumption.