What is Epitalon?
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed in Russia, modeled on a pineal-gland extract called epithalamin.
How does Epitalon work?
Cell studies report it can activate telomerase, the enzyme that maintains the protective caps (telomeres) on chromosomes.
What are researchers studying?
- ●Telomere length in cell cultures
- ●Aging models in animals
- ●Melatonin and circadian rhythms
Where does the evidence stand?
Not approved by the FDA. Much of the research comes from a single group of investigators and has not been widely replicated.
Quick facts
- Research area
- Longevity
- Sequence
Ala-Glu-Asp-Gly- Also known as
- Epithalon
- Third-party lab results
- 2 published COAs →
- Tested vendors tracking it
- 2 vendors →
Recent peer-reviewed research
The most relevant Epitalon studies from the last three years, via PubMed (U.S. National Library of Medicine).
- Synthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety StandardsInternational journal of pharmaceutical compounding · 2026 Jul-Aug · PubMed ↗
- The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic RetinopathyStem cell reviews and reports · 2025 Aug · PubMed ↗
- Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo developmentLife sciences · 2025 Feb 1 · PubMed ↗
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activityBiogerontology · 2025 Sep 4 · PubMed ↗
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising PropertiesInternational journal of molecular sciences · 2025 Mar 17 · PubMed ↗
Compare Epitalon
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This guide summarizes published research for educational purposes only. It is not medical advice and does not describe how to use Epitalon. Citations link to PubMed and are listed for reference — we haven't reviewed or endorsed their findings. Products referenced on The Peptide Audit are sold by third parties for laboratory research use only and are not for human consumption.