What is Semax?
Semax is a synthetic seven-amino-acid peptide derived from a fragment of ACTH (adrenocorticotropic hormone), developed in Russia.
How does Semax work?
Studies suggest it raises brain-derived neurotrophic factor (BDNF) and influences dopamine and serotonin signaling, without ACTH’s hormonal effects.
What are researchers studying?
- ●Stroke recovery (clinical use in Russia)
- ●Attention and memory in animal models
- ●Nerve-cell protection
Where does the evidence stand?
Approved as a medicine in Russia. Not approved by the FDA.
Quick facts
- Research area
- Cognitive
- Sequence
Met-Glu-His-Phe-Pro-Gly-Pro- Third-party lab results
- 5 published COAs →
- Tested vendors tracking it
- 2 vendors →
Recent peer-reviewed research
The most relevant Semax studies from the last three years, via PubMed (U.S. National Library of Medicine).
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future DirectionsJournal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026 Jan 1 · PubMed ↗
- Therapeutic peptides in gerontology: mechanisms and applications for healthy agingFrontiers in aging · 2026 · PubMed ↗
- ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental StrokeBiomedicines · 2024 Dec 13 · PubMed ↗
- Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female miceBritish journal of pharmacology · 2025 Nov · PubMed ↗
- The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain NeuronsBulletin of experimental biology and medicine · 2025 Aug · PubMed ↗
Compare Semax
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This guide summarizes published research for educational purposes only. It is not medical advice and does not describe how to use Semax. Citations link to PubMed and are listed for reference — we haven't reviewed or endorsed their findings. Products referenced on The Peptide Audit are sold by third parties for laboratory research use only and are not for human consumption.