What is DSIP?
DSIP (delta sleep-inducing peptide) is a nine-amino-acid peptide first isolated in 1977 from rabbits in induced sleep.
How does DSIP work?
Its mechanism remains unclear; no specific receptor has been identified, and it may act on several systems including stress hormones.
What are researchers studying?
- ●Sleep architecture
- ●Stress and pain responses
- ●Withdrawal symptoms in early studies
Where does the evidence stand?
Not approved by the FDA. Results from human sleep studies have been inconsistent.
Quick facts
- Research area
- Sleep
- Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu- Also known as
- Delta Sleep
- Third-party lab results
- 4 published COAs →
- Tested vendors tracking it
- 2 vendors →
Recent peer-reviewed research
The most relevant DSIP studies from the last three years, via PubMed (U.S. National Library of Medicine).
- Practical N-to-C peptide synthesis with minimal protecting groupsCommunications chemistry · 2023 Oct 26 · PubMed ↗
- Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse modelsFrontiers in pharmacology · 2024 · PubMed ↗
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This guide summarizes published research for educational purposes only. It is not medical advice and does not describe how to use DSIP. Citations link to PubMed and are listed for reference — we haven't reviewed or endorsed their findings. Products referenced on The Peptide Audit are sold by third parties for laboratory research use only and are not for human consumption.